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BioTech / Pharma Product Line(s)

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NuGenTec's BioTech Product Line has been carefully selected and sourced to provide the highest quality and purity. Our select line of BioTech / Pharma Chemicals meets the most stringent standards current to the industry. Our Class 100 CleanRoom blending and filling area is specifically designed with the needs of the BioTech and Semiconductor Industries in mind. Nugentec is unique in the range of products available and offers a level of customer service that sets us apart from the competition. With the ideal of constant improvement and the needs of our customers, we believe NuGenTec can and will prove to be a leader in the industry. We are committed and dedicated to serve you to the very best of our ability. We look forward to establishing and maintaining the quality relationship which you deserve.

NuGenTec is the only authorized down-packer of BASF Pharma/BioTech Products in the USA

CORE PRODUCTS:

  • Acetone

  • Acetonitrile

  • DMF (Dimethylformamide)
    • DMF is a solvent with a low evaporation rate. Used as a solvent in peptide coupling for pharmaceuticals.
    • Fmoc solid-phase peptide synthesis: To remove an Fmoc from a growing peptide chain, basic conditions (usually 20% piperidine in DMF) are used.
    • Alloc protecting group: used to wash off resin.
    • Protected amino acids dissolved in a solvent such as dimethylformamide (DMF)

  • IPA (Isopropyl Alcohol)

  • Methanol (methyl alcohol)

  • Methylene Chloride (DCM)

  • NMP (N-Methyl-2-pyrrolidone, N-Methyl Pyrrolidone): is the lactam of 4-methylaminobutyric acid and a very weak base. NMP is a chemically stable and powerful polar solvent. These characteristics are highly useful in a variety of chemical reactions where an inert medium is of concern. Despite the stability of NMP, it can also play an active role in certain reactions: hydrolysis, oxidation, condensation, conversion with chlorinating agents, polymerization and o-alkylation, and related reactions
    • PEG based Resins

  • Piperidine
    • Fmoc solid-phase peptide synthesis: To remove an Fmoc from a growing peptide chain, basic conditions (usually 20% piperidine in DMF) are used.
    • ***(Listed on US Controlled Substances Act)***
      • Purchasing Requirements
        1. DEA Licence Mandatory for Purchase
        2. NuGenTec BioTech Sales must approve your company before an order may be placed.
          1. On-Site Inspection Required.
          2. All DEA forms on File.
          3. NO COD or CASH or Will Call orders.

  • 4-MethylPiperidine
    • Fmoc solid-phase peptide synthesis: To remove an Fmoc from a growing peptide chain, basic conditions (usually 20% 4-MethylPiperidine in DMF) are used.
    • Not listed on US Controlled Substances Act. Used in lue of Piperidine

Products listed above supplied in bulk, 55-gallon drums, 5-gallon pails and 4x1-gallon cases.


A great short course video Biochemistry: The Amino Acids, Peptides, and Proteins. Courtesy of MIT / CHEMISTRY

By Donald R. Sadoway

Watch it on Academic Earth

COURSE DESCRIPTION

This course explores the basic principles of chemistry and their application to engineering systems. It deals with the relationship between electronic structure, chemical bonding, and atomic order. It also investigates the characterization of atomic arrangements in crystalline and amorphous solids: metals, ceramics, semiconductors, and polymers (including proteins). Topics covered include organic chemistry, solution chemistry, acid-base equilibria, electrochemistry, biochemistry, chemical kinetics, diffusion, and phase diagrams. Examples are drawn from industrial practice (including the environmental impact of chemical processes), from energy generation and storage, e.g., batteries and fuel cells, and from emerging technologies, e.g., photonic and biomedical devices. 


BIOPROCESSING Biomaterials news

Scientific American - Biotechnology
Mapping the Mind: Online Interactive Atlas Shows Activity of 20,000 Brain-Related Genes (preview)

Scientists have long sought to understand the biological basis of thought. In the second century A.D., physician and philosopher Claudius Galen held that the brain was a gland that secreted fluids to the body via the nerves--a view that went unchallenged for centuries. In the late 1800s clinical researchers tied specific brain areas to dedicated functions by correlating anatomical abnormalities in the brain after death with behavioral or cognitive impairments. French surgeon Pierre Paul Broca, for example, found that a region on the brain’s left side controls speech. In the first half of the 20th century, neurosurgeon Wilder Penfield mapped the brain’s functions by electrically stimulating different places in conscious patients during neurosurgery, triggering vivid memories, localized body sensations, or movement of an arm or toe.

In recent years new noninvasive ways of viewing the human brain in action have helped neuroscientists trace the anatomy of thought and behavior. Using functional magnetic resonance imaging, for instance, researchers can see which areas of the brain “light up” when people perform simple movements such as lifting a finger or more complex mental leaps such as recognizing someone or making a moral judgment. These images reveal not only how the brain is divided functionally but also how the different areas work together while people go about their daily activities. Some investigators are using the technology in an attempt to detect lies and even to predict what kinds of items people will buy; others are seeking to understand the brain alterations that occur in disorders such as depression, schizophrenia, autism and dementia.

[More]

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Brain - Functional magnetic resonance imaging - Neurosurgery - Health - Human brain
New Microscope Enables Real-Time 3-D Movies of Developing Embryos [Slide Show]

Using a revolutionary new microscope, scientists can now peer into embryos and watch, in one of the world's smallest 3-D movies, as brains, eyes and other organs form. A team at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, watched zebra fish and fruit fly embryos develop under the scope for as long as 58 hours, charting the location of every cell as it danced around the embryo. This experiment would have been impossible a mere two years ago before a recent spate of innovations advanced microscopy years into the future.

When it comes to watching the inner workings of cells , fluorescence microscopy is second to none. In this technique, scientists attach fluorescent tags to cellular proteins and, by shining a laser on the cells, cause them to light up.

[More]

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European Molecular Biology Laboratory - Heidelberg - Embryo - Biology - Zebrafish
Attractive Therapy: Magnetic Brain Stimulation Gaining Favor as Treatment for Depression

Treatment of severe depression with magnetic stimulation is moving beyond large mental health centers and into private practices nationwide, following more than two decades of research on the treatment. Yet even as concern about its efficacy fades, one potential side effect--seizures--continues to shadow the technology. [More]

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Mental health - Health - Major depressive disorder - Disorders - Mood

Wheat and apple DNA sequenced, providing clues that may help eliminate famine

An apple a day keeps the doctor away, but can knowing its genetic secrets help feed the nine billion people expected on this planet by 2050? Scientists hope so, especially considering they have added wheat this week to the list of crops that have had their genetic instruction set read. [More]

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Wheat - DNA - Apple - Agriculture - University of Liverpool

Stem Cells from Reprogrammed Adult Cells Found to Bring Along Genetic Defects of Their Donors

Realistic stem cell therapies to replace diseased or damaged tissue may still be years away, but researchers have uncovered a promising new use for these undifferentiated cells: they can be programmed to become patient-specific laboratory models of inherited liver disease. These new tools could be useful for teasing out disease mechanisms and testing new drug therapies.

Scientists from the University of Cambridge's Institute for Medical Research obtained skin cells from 10 patients--seven who had various forms of inherited liver disease, and three healthy controls. They reprogrammed the skin cells, rejuvenating them into an embryolike state (using the four-gene approach described in 2007). The researchers then cultured these so-called induced pluripotent stem cells (iPS cells) in a mixture of chemical factors that triggered their conversion into liver cells, which had the appearance and functional properties of native liver cells.

[More]

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Stem cell - Cambridge University - Medical Research - Liver - Induced pluripotent stem cell
New 3-D model shows how proteins bind to DNA packages

Inside cells, some DNA is wound into tight packets , known as nucleosomes. Special enzymes bind to these compact packages of genetic material, helping to activate genes . But just how the crucial binding happens in three-dimensional space was unclear. [More]

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DNA - Protein - Gene - Biology - Biochemistry and Molecular Biology

Staying Negative: How an Unexpected Antiretroviral Result Is Reshaping the Battle Against AIDS

When the first positive results of a research trial for an antiretroviral-based vaginal microbicide gel were announced at the International AIDS Conference in Vienna this July, it marked a significant thinning of the line between HIV treatment and prevention. The same agents that had been designed and developed to slow the virus's proliferation within the human body  now had the potential to be used to help bar it from successfully setting up shop in the first place. [More]

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HIV - Vienna - Antiretroviral drug - Health - Conditions and Diseases

A Failed "War on Drugs" Prompts Rethinking on HIV Infections among Injection-Drug Users

The "War on Drugs" has failed, particularly with regard to the spread of HIV in middle-income nations and some developing nations in Asia. The disease is now starting to bleed into Africa as well. [More]

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War on Drugs - Drugs - HIV - Health - Africa

Can Exercise Make You Feel More Full?

By a simple food-in/energy-out model, a run on the treadmill or swim in the pool should make you want to eat more. But recent findings have suggested that exercise can actually help to slow overeating. And a new study presents evidence that the body's physiologic response to exercise can help retune the nervous system's cues and make the body feel less hungry, rather than more so. [More]

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Treadmill - Shopping - Sports - Fitness - Television

Laying Odds on the Apocalypse: Experts Assess Doomsday (preview)

With all due respect to T. S. Eliot, maybe the world really does end with a bang, not a whimper. Whether of our own creation (nuclear holocaust) or of nature’s (asteroid impact), plenty of cataclysms could doom civilization--perhaps even putting the survival of the species in jeopardy. We assessed the likelihood of several doomsday scenarios, from oft-discussed threats such as climate change to more fanciful ideas such as quantum fluctuations that would destroy our universe. The probabilities listed here are not scientific fact--an impossible goal when estimating the possibility of unprecedented events--but informed conjecture based on researchers’ expert opinions. We also relied on those opinions to approximate how catastrophic each event would be, ranging from 1 (localized chaos) to 10 (good-bye, universe).

KILLER PANDEMIC [More]

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Climate change - Environment - T. S. Eliot - Species - Probability

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